Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic by Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. PDF

By Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)

Amino Acids Biosynthesis provides the present wisdom of basic in addition to utilized microbiology of amino acids. subject matters mentioned are the amino acid biosynthetic pathways, their genetic and biochemical law, delivery of amino acids and genomics of manufacturing microorganisms. The characterization of the regulate mechanisms of amino acid biosynthesis has printed insights into rules of genetic and biochemical law, akin to transcriptional regulators and a brand new type of regulatory parts, the riboswitch.

The quantity extra bargains with the metabolic engineering of microorganisms for the biotechnological construction of amino acids to be used as prescribed drugs and, really, as foodstuff and feed ingredients. accomplished stories are given of modern achievements to allow or increase creation of amino acids and dipeptides via fermentation and enzyme catalysis. the following, the actual concentration is on metabolic engineering, the rational development of metabolic features utilizing recombinant DNA technology.

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Results are summarized in Table 2. In both coryneform bacteria, the Km values of GDH were 50- to 100-fold higher than those of ICDH and ODHC. Therefore, Production of Glutamate and Glutamate-Related Amino Acids 23 Table 2 Comparison of Km values (mM) of enzymes around 2-oxoglutarate Enzyme C. glutamicum C. 99) Km of ICDH for isocitrate and those of ODHC and GDH for 2-oxoglutarate are shown. Bracket values for each enzyme indicate sum of residual square (r2 values) for Lineweaver–Burk plot the affinity of 2-oxoglutarate for GDH was much lower than that for ODHC.

Microbiol Rev 53:121–147 Csonka LN, Gelvin SB, Goodner BW, Orser CS, Siemieniak D, Slightom JL (1988) Nucleotide seqence of a mutation in the proB gene of Escherichia coli that confers proline overproduction and enhanced tolerance to osmotic stress. Gene 64:199–205 Dauner M, Sauer U (2000) GC-MS analysis of amino acids rapidly provides rich information for isotomoper balancing. Biotechnol Prog 16:642–649 Delaunay S, Gourdon O, Lapujade P, Mailly E, Oriol E, Engasser JM, Lindley ND, Goergen J-L (1999) An improved temperature-triggered process for glutamate production with Corynebacterium glutamicum.

2003). Extensive biochemical studies in the last decades as reviewed in a recent handbook on Corynebacterium glutamicum (Eggeling and Bott 2005) and the recent unravelling of the genome sequence (Haberhauer et al. 2001; Ikeda and Nakagawa 2003; Tauch et al. 2002; Kalinowski et al. 2003) have contributed to a detailed knowledge of the reactions of lysine biosynthesis and central metabolism in this microorganism (Fig. 4).

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