Download e-book for iPad: Autophagy in Infection and Immunity by Zhifen Yang, Daniel J. Klionsky (auth.), Beth Levine,

By Zhifen Yang, Daniel J. Klionsky (auth.), Beth Levine, Tamotsu Yoshimori, Vojo Deretic (eds.)

Autophagy is a basic organic technique that allows cells to autodigest their very own cytosol in the course of hunger and other kinds of rigidity. It has a growing to be spectrum of stated roles in immunity, getting older, improvement, neurodegeneration, and melanoma biology. An immunological position of autophagy used to be first well-known with the invention of autophagy’s skill to sanitize the mobile inside by means of killing intracellular microbes. on account that then, the repertoire of autophagy’s roles in immunity has been tremendously accelerated to incorporate a various yet interconnected portfolio of regulatory and effector capabilities. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes primary tolerance; it impacts B and T mobile homeostasis; it acts either as an effector and a regulator of Toll-like receptor and different innate immunity receptor signaling; and it could actually aid beat back power inflammatory affliction in people. With this sort of multitude of innate and adaptive immunity services, the examine of autophagy in immunity is without doubt one of the such a lot speedily turning out to be fields of latest immunological examine. This booklet introduces the reader to the basics of autophagy, publications a amateur and the well-informed reader alike via diverse immunological points of autophagy in addition to the countermeasures utilized by hugely tailored pathogens to struggle autophagy, and gives the professional with the most recent, up to date info at the specifics of the vanguard of autophagy examine in an infection and immunity.

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Additional resources for Autophagy in Infection and Immunity

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J Cell Sci 116:1679–88 Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular self-digestion. Nature 451:1069–1075 Monastyrska I, Shintani T, Klionsky DJ, Reggiori F (2006) Atg11 directs autophagosome cargoes to the PAS along actin cables. Autophagy 2:119–121 Monastyrska I, He C, Geng J, Hoppe AD, Li Z, Klionsky DJ (2008) Arp2 links autophagic machinery with the actin cytoskeleton. Mol Biol Cell 19:1962–1975 Nair U, Klionsky DJ (2005) Molecular mechanisms and regulation of specific and nonspecific autophagy pathways in yeast.

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Mol Cell 26:663–674 Veenhuis M, Douma A, Harder W, Osumi M (1983) Degradation and turnover of peroxisomes in the yeast Hansenula polymorpha induced by selective inactivation of peroxisomal enzymes. Arch Microbiol 134:193–203 Wang C-W, Klionsky DJ (2003) The molecular mechanism of autophagy. Mol Med 9:65–76 32 Z. J. Klionsky Wang C-W, Kim J, Huang W-P, Abeliovich H, Stromhaug PE, Dunn WA Jr, Klionsky DJ (2001a) Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways.

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